One of my instructors in college had his keyboard with no letters on the keys set at a Dvorak keyboard rather than QWERTY; it drove people crazy when they tried to do anything on his machine (We were doing Novell without the GUI).Computer mouse actually works better on the left side for me. It's closer to the keyboard. If the mouse is on the right you have to jump over the location keys and numeric keypad to get to it. Score 1 for the left-handed!
Now, I have to switch the mouse buttons by physically hard-wiring them. But then the buttons always work correctly, even for terrible operating systems (*cough* windows *cough*) and poorly-written programs (usually Java-based). Bonus: Fun watching righty's try to use my computer.
Back on the Elio, I think we will find a much-higher than average number of left-handed people in the early-adopters. Overgeneralizing, lefties tend to be more-open to different ideas because, as Chaz said, we have to be to survive in a world that doesn't fit us.
(P.S. Lefties have shorter life spans. I speculate it's because all of the World's safety systems are designed by right-handed people by right-handed people. It's Lefticide! )